Dastgheib K, Green W R
Eye Pathology Laboratory, Wilmer Ophthalmological Institute, Baltimore, Md.
Arch Ophthalmol. 1994 Jun;112(6):813-8. doi: 10.1001/archopht.1994.01090180111045.
The histopathologic features of a granulomatous reaction in one eye of a patient with neovascular age-related macular degeneration are presented. Multiple multinucleated giant cells were found in intimate association with Bruch's membrane and at the margin of Bruch's membrane defects. Multinucleated giant cells appear to participate in the breakdown of Bruch's membrane and, together with diffuse disease of the retinal pigment epithelium and changes in the physicochemical properties of Bruch's membrane, may provide angiogenic stimulus for choroidal neovascularization in age-related macular degeneration.
本文呈现了一位患有新生血管性年龄相关性黄斑变性患者一只眼睛中肉芽肿反应的组织病理学特征。在与布鲁赫膜紧密相连处以及布鲁赫膜缺损边缘发现了多个多核巨细胞。多核巨细胞似乎参与了布鲁赫膜的破坏，并且与视网膜色素上皮的弥漫性病变以及布鲁赫膜理化性质的改变一起，可能为年龄相关性黄斑变性中的脉络膜新生血管形成提供血管生成刺激。
