Hawkins P N, Rossor M N, Gallimore J R, Miller B, Moore E G, Pepys M B
Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Biochem Biophys Res Commun. 1994 Jun 15;201(2):722-6. doi: 10.1006/bbrc.1994.1760.
Serum amyloid P component (SAP) is a normal plasma protein produced in the liver and co-deposited with amyloid fibrils in all types of amyloidosis, including cerebral beta-protein amyloid deposits associated with Alzheimer's disease (AD). We have measured its concentration and those of alpha 2-macroglobulin, IgG and albumin in the CSF of 51 patients with AD and 50 healthy and disease control subjects. The mean levels of SAP were 12.8 ng/ml in AD and 8.5 ng/ml in controls (P < 0.0125); there was no difference in the levels of the other proteins studied. The observed concentrations of SAP were much lower than expected for a protein of molecular weight 254620. The difference between AD and controls suggests that the concentration of SAP in the CSF may be affected by the presence of cerebral amyloidosis.
血清淀粉样蛋白P成分（SAP）是一种在肝脏中产生的正常血浆蛋白，在所有类型的淀粉样变性中都与淀粉样纤维共同沉积，包括与阿尔茨海默病（AD）相关的脑β蛋白淀粉样沉积。我们测量了51例AD患者以及50名健康对照者和疾病对照者脑脊液中SAP、α2巨球蛋白、IgG和白蛋白的浓度。AD患者中SAP的平均水平为12.8 ng/ml，对照组为8.5 ng/ml（P < 0.0125）；所研究的其他蛋白质水平没有差异。观察到的SAP浓度远低于分子量为254620的蛋白质的预期浓度。AD患者与对照组之间的差异表明，脑脊液中SAP的浓度可能受脑淀粉样变性的影响。
