Ogomori K, Kitamoto T, Tateishi J, Sato Y, Suetsugu M, Abe M
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Am J Pathol. 1989 Feb;134(2):243-51.
To clarify the distribution, morphology, and density of amyloid deposits in patients with Alzheimer's disease (AD), tissue sections from various areas of the central nervous system of 14 patients with AD and from 20 nondemented aged controls were investigated immunohistochemically using anti-beta protein antiserum. beta-protein amyloid deposits were present not only in the cores of the senile plaques and in the vascular wall (amyloid angiopathy), but also in various sized plaque-shaped fibrillary, perivascular, subpial, and subependymal deposits. Amyloid deposits were found mainly in the cerebral cortex in nondemented controls, while in AD they were distributed widely in the regions that were not affected in nondemented controls. The positivity of amyloid deposits in AD was 100% in the cerebral cortex, hippocampus, amygdala, thalamus, caudate nucleus, claustrum, hypothalamus, nucleus basalis of Meynert, and cerebellar cortex. Putamen and brain-stem nuclei were affected frequently, and the spinal cord, dentate nucleus, and globus pallidus were sometimes (less than 50%) affected. This result provides an evidence that Alzheimer's disease is a beta-protein amyloidosis of the central nervous system. An assessment of the distribution of amyloid deposits should prove to be useful for the histopathologic diagnosis of AD.
为明确阿尔茨海默病（AD）患者淀粉样沉积物的分布、形态和密度，使用抗β蛋白抗血清对14例AD患者及20例非痴呆老年对照者中枢神经系统不同区域的组织切片进行免疫组织化学研究。β蛋白淀粉样沉积物不仅存在于老年斑核心及血管壁（淀粉样血管病），还存在于各种大小的斑块状纤维、血管周围、软膜下及室管膜下沉积物中。淀粉样沉积物在非痴呆对照者中主要见于大脑皮质，而在AD患者中，它们广泛分布于非痴呆对照者未受影响的区域。AD患者淀粉样沉积物在大脑皮质、海马、杏仁核、丘脑、尾状核、屏状核、下丘脑、Meynert基底核及小脑皮质中的阳性率为100%。壳核和脑干核经常受累，脊髓、齿状核及苍白球有时（少于50%）受累。这一结果证明阿尔茨海默病是一种中枢神经系统β蛋白淀粉样变性。评估淀粉样沉积物的分布对AD的组织病理学诊断应是有用的。
