Tsang Y T, Haskard D O, Robinson M K
Celltech Research, Celltech Ltd., Slough, UK.
Biochem Biophys Res Commun. 1994 Jun 15;201(2):805-12. doi: 10.1006/bbrc.1994.1772.
Human vascular cell adhesion molecule is believed to play a key role in recruiting leukocytes to sites of injury. Here we report the identification of a homologous molecule in the pig which has five Ig domains and an overall 77% homology with the human protein. The expression of this protein was also characterised on porcine endothelial cells. Like the human adhesion molecule, the porcine protein could be induced by LPS, TNF and IL-1 alpha, although differences were noted in the kinetics of expression.
人们认为人类血管细胞黏附分子在将白细胞募集到损伤部位的过程中起关键作用。在此我们报告在猪体内鉴定出一种同源分子，它有五个免疫球蛋白（Ig）结构域，与人类蛋白的总体同源性为77%。还对该蛋白在猪内皮细胞上的表达特征进行了研究。与人类黏附分子一样，猪蛋白可被脂多糖（LPS）、肿瘤坏死因子（TNF）和白细胞介素-1α（IL-1α）诱导，不过在表达动力学方面存在差异。
