Gu Q, Liu Y, Cynader M S
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Brain Res. 1994 Mar 21;640(1-2):336-40. doi: 10.1016/0006-8993(94)91890-2.
The localization of tachykinin-immunoreactivity in the cat visual cortex (area 17) was investigated using immunohistochemical methods. Strong laminar specificity was observed, with immunoreactivity highest in layer V, followed by layers I, VI, II and III, and the lowest density in layer IV. Most of the immunoreactive product was localized in neuronal processes. A few immunopositive cell bodies were also present. The immunopositive neurons were non-pyramidal, multipolar, or bipolar in shape, and mostly found in layer V. There were particularly dense immunopositive fibers and varicosities around somata in layer V. These may represent tachykinin-containing presynaptic terminals (boutons). The results provide anatomical evidence that tachykinins may primarily affect layer V neurons in the cat visual cortex.
采用免疫组织化学方法研究了速激肽免疫反应性在猫视皮层（17区）的定位。观察到强烈的层特异性，免疫反应性在V层最高，其次是I、VI、II和III层，IV层密度最低。大部分免疫反应产物定位于神经元突起。也存在一些免疫阳性细胞体。免疫阳性神经元呈非锥体、多极或双极形态，主要见于V层。V层中胞体周围有特别密集的免疫阳性纤维和曲张体。这些可能代表含速激肽的突触前终末（boutons）。结果提供了解剖学证据，表明速激肽可能主要影响猫视皮层的V层神经元。
