Haddad M G, Silverman J F
Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Diagn Cytopathol. 1994;10(1):15-9. doi: 10.1002/dc.2840100105.
Metastatic basal cell carcinomas of the skin are rare. We present the cytologic features of a metastatic basal cell carcinoma to the lung diagnosed by fine-needle aspiration biopsy. Cytologic examination revealed syncytial groups of relatively small cells with hyperchromatic, oval to spindle-shaped nuclei having high nuclear to cytoplasmic ratios. Immunocytochemical studies performed on the cell block sections revealed the malignant cells to be positive for cytokeratin (AE1/3) and negative for neuroendocrine markers, [neuron specific enolase (NSE) and chromogranin (Phe-5)]. We reviewed the literature related to metastatic basal cell carcinoma of the skin and discuss risk factors and mechanisms of metastatic spread. In addition, a discussion of the other entities that can enter into the differential diagnosis is presented along with the role of ancillary studies. To the best of our knowledge, we believe this is the first case report of the fine-needle aspiration (FNA) cytology of a basal cell carcinoma metastatic to the lung.
皮肤转移性基底细胞癌很罕见。我们报告了1例经细针穿刺活检诊断为肺转移性基底细胞癌的细胞学特征。细胞学检查显示，细胞呈合体细胞团状，细胞相对较小，核深染，呈椭圆形至梭形，核质比高。对细胞块切片进行的免疫细胞化学研究显示，恶性细胞细胞角蛋白（AE1/3）呈阳性，神经内分泌标志物[神经元特异性烯醇化酶（NSE）和嗜铬粒蛋白（Phe-5）]呈阴性。我们回顾了与皮肤转移性基底细胞癌相关的文献，并讨论了转移扩散的危险因素和机制。此外，还讨论了其他可能需要鉴别的病变以及辅助检查的作用。据我们所知，我们认为这是首例肺转移性基底细胞癌细针穿刺（FNA）细胞学的病例报告。
