Henke A C, Wiemerslage S J, Cohen M B
Department of Pathology, University of Iowa, Iowa City 52242-1009, USA.
Diagn Cytopathol. 1998 Aug;19(2):113-5. doi: 10.1002/(sici)1097-0339(199808)19:2<113::aid-dc9>3.0.co;2-f.
Although basal cell carcinoma is the most common malignant skin tumor, it rarely metastasizes. Because of the infrequency of basal cell carcinoma metastases, the cytomorphologic findings have not been well documented. We retrospectively reviewed the cytologic findings of six cases of metastatic basal cell carcinoma from two patients. Five of these specimens were fine-needle aspiration biopsies, and one was a bronchial brush specimen. All cases were confirmed by and compared to either the concurrent tissue biopsy or to a previous surgical specimen. The microscopic findings of these specimens reveal tight clusters of cells with high nuclear to cytoplasmic ratio. The nuclei were crowded and overlapping, and on Diff Quik stain, peripheral palisading of nuclei could be appreciated. The small hyperchromatic nuclei were round to oval with finely granular chromatin. Nucleoli were inconspicuous. Basophilic cytoplasm was scant with indistinct borders. Cytologic findings of basal cell carcinoma have not been well documented in the English literature. Our experience suggests that there are unique cytormorphologic features of metastatic basal cell carcinoma and that in the right setting such a diagnosis can be rendered.
尽管基底细胞癌是最常见的恶性皮肤肿瘤，但它很少发生转移。由于基底细胞癌转移情况罕见，其细胞形态学表现尚未得到充分记录。我们回顾性分析了两名患者的6例转移性基底细胞癌的细胞学表现。其中5份标本为细针穿刺活检，1份为支气管刷检标本。所有病例均经同期组织活检或既往手术标本证实并进行对比。这些标本的显微镜检查结果显示，细胞紧密聚集，核质比高。细胞核拥挤且相互重叠，在Diff Quik染色下，可观察到细胞核周边呈栅栏状排列。小的深染细胞核呈圆形至椭圆形，染色质细颗粒状。核仁不明显。嗜碱性细胞质稀少，边界不清。英文文献中对基底细胞癌的细胞学表现记录不足。我们的经验表明，转移性基底细胞癌具有独特的细胞形态学特征，在合适的情况下可以做出这样的诊断。
