Gemmell R T, Alexander G
Aust J Biol Sci. 1978 Oct;31(5):505-15. doi: 10.1071/bi9780505.
The development of subcutaneous and perirenal adipose tissue in foetal sheep of 40--150 days conceptual age was examined using electromicroscopy. Adipose tissue from both sites developed from pre-adipose cells of similar appearance, with few mitochondria, and commenced accumulating lipid on about day 70 of gestation. In the perirenal fat there was marked proliferation of mitochondria between days 80 and 90 and the tissue developed into brown fat, cell profiles being characterized by many mitochondria with numerous distinct cristae, whereas in the subcutaneous cells which developed into white adipose tissue few mitochondria with fewer cristae were observed. Multilocular and unilocular cells occurred in both tissues near term. Nerves were first seen between brown adipose cells in a 130-day-old foetus and were frequently seen in older foetuses, but very few nerves were seen in the white adipose tissue. In hypophysectomized foetuses, either full- or post-term, the subcutaneous fat and internal fat were shown to be white and brown adipose tissue respectively, as in normal foetuses, although in one 164-day-old foetus the perirenal tissue appeared to be a mixture of brown and white fat.
利用电子显微镜检查了受孕40 - 150天胎羊的皮下和肾周脂肪组织的发育情况。两个部位的脂肪组织均由外观相似、线粒体较少的前脂肪细胞发育而来，在妊娠约70天时开始积累脂质。在肾周脂肪中，80至90天期间线粒体显著增殖，该组织发育为棕色脂肪，细胞形态特征为许多线粒体且有众多明显的嵴，而发育为白色脂肪组织的皮下细胞中，观察到的线粒体较少且嵴也较少。临近足月时，两种组织中均出现了多泡和单泡细胞。在130天龄胎儿的棕色脂肪细胞之间首次发现神经，在较大胎儿中也经常可见，但在白色脂肪组织中很少见到神经。在全切除垂体或足月后的垂体切除胎儿中，皮下脂肪和内脏脂肪分别显示为白色和棕色脂肪组织，与正常胎儿一样，尽管在一个164天龄的胎儿中，肾周组织似乎是棕色和白色脂肪的混合物。
