Dodson Michael V, Du Min, Wang Songbo, Bergen Werner G, Fernyhough-Culver Melinda, Basu Urmila, Poulos Sylvia P, Hausman Gary J
Department of Animal Sciences; Washington State University ; Pullman, WA USA.
Department of Animal Sciences; Washington State University ; Pullman, WA USA ; College of Animal Science; South China Agricultural University ; Guangzhou, PR China.
Adipocyte. 2014 Dec 10;3(4):236-41. doi: 10.4161/adip.28321. eCollection 2014 Oct-Dec.
The race to manage the health concerns related to excess fat deposition has spawned a proliferation of clinical and basic research efforts to understand variables including dietary uptake, metabolism, and lipid deposition by adipocytes. A full appreciation of these variables must also include a depot-specific understanding of content and location in order to elucidate mechanisms governing cellular development and regulation of fat deposition. Because adipose tissue depots contain various cell types, differences in the cellularity among and within adipose depots are presently being documented to ascertain functional differences. This has led to the possibility of there being, within any one adipose depot, cellular distinctions that essentially result in adipose depots within depots. The papers comprising this issue will underscore numerous differences in cellularity (development, histogenesis, growth, metabolic function, regulation) of different adipose depots. Such information is useful in deciphering adipose depot involvement both in normal physiology and in pathology. Obesity, diabetes, metabolic syndrome, carcass composition of meat animals, performance of elite athletes, physiology/pathophysiology of aging, and numerous other diseases might be altered with a greater understanding of adipose depots and the cells that comprise them-including stem cells-during initial development and subsequent periods of normal/abnormal growth into senescence. Once thought to be dormant and innocuous, the adipocyte is emerging as a dynamic and influential cell and research will continue to identify complex physiologic regulation of processes involved in adipose depot physiology.
应对与脂肪过度沉积相关的健康问题的竞赛催生了大量临床和基础研究工作，旨在了解包括饮食摄入、代谢以及脂肪细胞脂质沉积等变量。要全面理解这些变量，还必须对脂肪储存部位的具体内容和位置有特定的认识，以便阐明控制细胞发育和脂肪沉积调节的机制。由于脂肪组织储存部位包含多种细胞类型，目前正在记录不同脂肪储存部位之间以及内部细胞构成的差异，以确定功能差异。这就引发了一种可能性，即在任何一个脂肪储存部位内，细胞差异实际上会导致“储存部位内的脂肪储存部位”的出现。本期的论文将强调不同脂肪储存部位在细胞构成（发育、组织发生、生长、代谢功能、调节）方面的众多差异。此类信息有助于解读脂肪储存部位在正常生理和病理过程中的作用。肥胖、糖尿病、代谢综合征、肉用动物的胴体组成、精英运动员的表现、衰老的生理/病理生理学以及许多其他疾病，可能会随着我们对脂肪储存部位以及构成它们的细胞（包括干细胞）在初始发育以及随后正常/异常生长直至衰老阶段的深入了解而发生改变。脂肪细胞曾被认为是静止且无害的，如今正逐渐成为一个活跃且具有影响力的细胞，并且研究将继续揭示脂肪储存部位生理学所涉及过程的复杂生理调节机制。
