Sasaki I, Fujii I
Department of Neuropsychiatry, Oita Medical University.
Nihon Rinsho. 1994 May;52(5):1323-8.
Firstly, we reviewed the drugs (ex, corticosteroid, interferon) which were thought to be related to organic mood disorders in the literature, and discussed a number of problems with assessment of drug-induced mental disorders. Next, we investigated 1) the antidepressant-induced switch rate from depression to mania and 2) the latency from administration to manic onset in three groups (Major depression: single episode, Major depression: recurrent, Bipolar disorder: depressed). Our data showed, 1) the switch rate was 17.2, 14.3, 32.0% and 2) the latency to onset was 69.9, 65.9, 37.1 days, respectively. The latency to onset showed no significant difference in three groups. (ANOVA, p < 0.05) Clomipramine, amitriptyline, imipramine, and dosulepin had the higher switch rate above 10%.
首先，我们回顾了文献中被认为与器质性心境障碍相关的药物（如皮质类固醇、干扰素），并讨论了药物性精神障碍评估中的一些问题。接下来，我们调查了三组（重度抑郁症：单次发作、重度抑郁症：复发、双相情感障碍：抑郁发作）中1）抗抑郁药诱发的从抑郁转为躁狂的转换率，以及2）从给药到躁狂发作的潜伏期。我们的数据显示，1）转换率分别为17.2%、14.3%、32.0%，2）发作潜伏期分别为69.9天、65.9天、37.1天。三组之间的发作潜伏期无显著差异。（方差分析，p<0.05）氯米帕明、阿米替林、丙咪嗪和多塞平的转换率高于10%。
