Imai K, Ichinose Y, Kubota Y, Yamanaka H, Sato J, Saitoh M, Watanabe H, Ohe H
Department of Urology, Gunma University School of Medicine.
Jpn J Clin Oncol. 1994 Jun;24(3):160-5.
The characteristics of serum prostate specific antigen (PSA) in normal Japanese men were studied in 1480 subjects examined by mass screening (MS) for prostate cancer (Pca) in Gunma Prefecture in 1992. The serum PSA concentration was correlated with patient age. The average serum PSA level increased by 0.04 ng/ml/year. The upper normal limits (95 percentiles) of age specific PSA for normal men are 1.33 ng/ml for those aged 39-49 years, 3.65 ng/ml for those aged 50-59 years, 4.06 ng/ml for those aged 60-69 years, 5.09 ng/ml for those aged 70-79 years and 5.66 ng/ml for those aged 80-89 years. Among 227 normal men examined by our MS in 1991 and 1992, the PSA velocity (PSAV) was calculated to be 0.05 ng/ml/year. Among 10 Pca patients with normal PSA levels (< 6 ng/ml) detected previously by our MS, three had an abnormal PSAV. We demonstrated the possibility that PSA density could distinguish between Pca and benign prostate hypertrophy. The significance of PSA as a Pca screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume estimated by sonography.
1992年，对群马县1480名接受前列腺癌大规模筛查（MS）的受试者进行了研究，以了解正常日本男性血清前列腺特异性抗原（PSA）的特征。血清PSA浓度与患者年龄相关。血清PSA平均水平每年升高0.04 ng/ml。正常男性年龄特异性PSA的正常上限（第95百分位数）为：39 - 49岁者为1.33 ng/ml，50 - 59岁者为3.65 ng/ml，60 - 69岁者为4.06 ng/ml，70 - 79岁者为5.09 ng/ml，80 - 89岁者为5.66 ng/ml。在1991年和1992年接受我们MS检查的227名正常男性中，PSA速率（PSAV）经计算为每年0.05 ng/ml。在我们之前的MS检查中检测出的10例PSA水平正常（<6 ng/ml）的前列腺癌患者中，有3例PSAV异常。我们证明了PSA密度可区分前列腺癌和良性前列腺增生的可能性。PSA作为前列腺癌筛查方式的意义应在多个年龄范围内进行评估，并结合既往PSA数据和/或超声估计的前列腺体积来判断。
