[S-腺苷甲硫氨酸在离体灌注大鼠肝脏中的掺入。初步研究]
[Incorporation of S-adenosylmethionine in the isolated and perfused rat liver. Preliminary study].
作者信息
Ruggiero G, Porcelli M, Andreana A, Cacciapuoti G, Zappia V
出版信息
Boll Soc Ital Biol Sper. 1978 Nov 15;54(21):2086-90.
PMID:751663
Abstract
The uptake of labeled S-adenosylmethionine (SAM) by isolated and perfused rat liver has been compared to that of methionine: the rate of incorporation of the amino acid exceeds by about three times that of the sulfonium compound. S-Adenosylmethionine transport system shows saturation kinetics with an apparent Km of 59,5 microM and is energy-dependent, as demonstrated by the inhibition by 2,4-dinitrophenol.
摘要
已将标记的S-腺苷甲硫氨酸（SAM）被分离并灌注的大鼠肝脏摄取的情况与甲硫氨酸的摄取情况进行了比较：氨基酸的掺入速率比锍化合物的掺入速率高出约三倍。S-腺苷甲硫氨酸转运系统表现出饱和动力学，表观Km为59.5微摩尔，并且是能量依赖性的，这一点已通过2,4-二硝基苯酚的抑制作用得到证明。
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