Castello G, Lerza R, Mencoboni M, Cavallini D, Flego G, Cerruti A, Ballarino P, Bogliolo G, Pannacciulli I
Department of Internal Medicine, University of Genoa, Italy.
Anticancer Res. 1994 Mar-Apr;14(2B):621-5.
Data are presented on the general and hematological toxicity of a cisplatin (DDP), 5-fluorouracil (5-FU) and alpha interferon (IFN-alpha) association in patients with stage III B or IV non small cell lung cancer (NSCLC). Twenty patients received DDP (100 mg/mq i.v., day 1) and 5-FU (750 mg/mq/day i.v. continuous infusion, days 1 to 4). In ten of these patients IFN-alpha (3 MU s.c., three times weekly, days 1 to 21) was added. General and hematological toxicity was of a similar degree in both groups. Recombinant granulocyte colony stimulating factor (G-CSF; 5 micrograms/kg b.w. s.c. days 7 to 18) induced a sharp increase in peripheral blood GM-CFU level in patients receiving DDP and 5-FU but not in DDP, 5-FU, IFN-alpha treated patients. The results appear to indicate that IFN-alpha modulation of a DDP, 5-FU combination induces an acceptable degree of toxicity.
本文呈现了顺铂（DDP）、5-氟尿嘧啶（5-FU）和α干扰素（IFN-α）联合用药对ⅢB期或Ⅳ期非小细胞肺癌（NSCLC）患者的一般毒性和血液学毒性数据。20例患者接受顺铂（100mg/m²静脉注射，第1天）和5-氟尿嘧啶（750mg/m²/天静脉持续输注，第1至4天）治疗。其中10例患者加用α干扰素（3MU皮下注射，每周3次，第1至21天）。两组的一般毒性和血液学毒性程度相似。重组粒细胞集落刺激因子（G-CSF；5μg/kg体重皮下注射，第7至18天）使接受顺铂和5-氟尿嘧啶治疗的患者外周血GM-CFU水平急剧升高，但对接受顺铂、5-氟尿嘧啶和α干扰素治疗的患者无效。结果似乎表明，α干扰素对顺铂、5-氟尿嘧啶联合用药的调节作用可诱导出可接受程度的毒性。
