Munno I, Marinaro M, Gesario A, Cannuscio B, Michel Y, Paulling E
Istituto di Microbiologia, University of Bari, Italy.
Clin Diagn Lab Immunol. 1995 Jul;2(4):503-5. doi: 10.1128/cdli.2.4.503-505.1995.
In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up-regulation of some immune parameters such as the CD4(+)-CD8+ cell-dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy.
在本报告中，我们评估了α干扰素（IFN-α）与胸腺刺激素（TP-1）联合给药以及单独使用IFN-α和TP-1对接受手术并随后接受传统化疗的肿瘤患者的免疫效果。数据表明，IFN-α与TP-1联合使用在上调某些免疫参数（如CD4(+)-CD8+细胞依赖性抗菌活性）方面最为有效。由于这种免疫功能在宿主抵御不同靶点（如入侵微生物和/或肿瘤细胞）的保护中发挥着重要作用，因此对于接受化疗的肿瘤患者，建议使用TP-1-IFN-α。
