Lippe C, Bellantuono V, Castronuovo G, Ardizzone C, Cassano G
Institute of General Physiology, University of Bari, Italy.
Arch Int Physiol Biochim Biophys. 1994 Jan-Feb;102(1):51-4. doi: 10.3109/13813459408996105.
Capsaicin at low concentrations increases the short circuit current (SCC) across frog skin. Simultaneous measurements of both transepithelial fluxes of 22Na or 36Cl demonstrate that the SCC increase is due to stimulation of sodium active absorption. Capsaicin acts through the liberation of several peptides; thus these peptides were tested on the SCC across frog skin. Those more active are, in order of potency: Cyclic Calcitonin Gene Related Peptide (CGRP), Kassinin and Eledoisin, Substance P (SP) and Neurokinin A. Neurokinin B and Vasoactive Intestinal Peptide (VIP) have no effect. Also the actions of SP and CGRP are due mainly to stimulation of Na+ active absorption. A strict parallelism regarding the sensitivity to inhibitors (Naproxen, SQ22536 and CP96345) between SP, CGRP and Capsaicin strengthens the hypothesis that SP and CGRP are liberated by Capsaicin in this tissue.
低浓度的辣椒素可增加蛙皮的短路电流（SCC）。对²²Na或³⁶Cl跨上皮通量的同步测量表明，SCC的增加是由于钠主动吸收受到刺激。辣椒素通过释放几种肽起作用；因此，对这些肽进行了蛙皮SCC测试。活性较高的依次为：环降钙素基因相关肽（CGRP）、蛙皮素和异蛙皮素、P物质（SP）和神经激肽A。神经激肽B和血管活性肠肽（VIP）无作用。此外，SP和CGRP的作用主要是由于刺激了Na⁺主动吸收。SP、CGRP和辣椒素对抑制剂（萘普生、SQ22536和CP96345）的敏感性存在严格的平行关系，这强化了SP和CGRP在该组织中由辣椒素释放的假说。
