Klimov A N, Denisenko A D, Belotserkovskiĭ M V, Gurevich K Ia, Vinogradov A G, Makoveĭchuk E G, Vasil'eva L E, Oleĭnik I A, Tikhonova L N, Sitnikova O D
Vestn Ross Akad Med Nauk. 1994(4):37-42.
The efficacy of extracorporeal cryohemosorption was estimated in the treatment of atherosclerotic patients in terms of the autoimmune theory of the pathogenesis of this disease. There was a slight decrease in the plasma levels of total cholesterol and triglycerides, there was over 2-fold reduction in the plasma levels of fibrinogen and fibronectin. All major components of apo B-containing lipoproteins and immunoglobulin G were found as part of the cryoprecipitate. An extremely high concentration of lipid hydroperoxides in the precipitate suggest that cryoprecipitation removes not only autoimmune complexes, but highly-atherogenic peroxide-modified lipoproteins. The three-fold decrease in the levels of lipoprotein-antibody complexes resulted in lower atherogenicity of apo B-containing lipoproteins. It is suggested that the mechanism responsible for beneficial clinical action of cryohemosorption sessions is largely associated with the removal of autoimmune lipoprotein-antibody complexes and peroxide-modified apo B-containing lipoproteins than correction of lipid metabolism.
根据动脉粥样硬化疾病发病机制的自身免疫理论，评估了体外冷冻血液吸附法治疗动脉粥样硬化患者的疗效。总胆固醇和甘油三酯的血浆水平略有下降，纤维蛋白原和纤连蛋白的血浆水平降低了2倍以上。含载脂蛋白B的脂蛋白和免疫球蛋白G的所有主要成分都被发现是冷沉淀物的一部分。沉淀物中极高浓度的脂质氢过氧化物表明，冷沉淀不仅能清除自身免疫复合物，还能清除高度致动脉粥样硬化的过氧化物修饰脂蛋白。脂蛋白 - 抗体复合物水平下降三倍，导致含载脂蛋白B的脂蛋白的致动脉粥样硬化性降低。有人认为，冷冻血液吸附治疗产生有益临床作用的机制在很大程度上与清除自身免疫性脂蛋白 - 抗体复合物和过氧化物修饰的含载脂蛋白B的脂蛋白有关，而不是与脂质代谢的纠正有关。
