血小板活化因子（PAF）对小鼠皮下植入物中血管形成的影响。
Effect of platelet activating factor (PAF) on the formation of blood vessels in subcutaneous implants in mice.
作者信息
Andrade S P, Vieira L B, Bakhle Y S, Piper P J
机构信息
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
出版信息
J Lipid Mediat Cell Signal. 1994 Mar;9(2):117-21.
Angiogenesis accompanies inflammatory processes and many other pathological conditions. We have studied the effect of platelet-activating factor (PAF) a well-known inflammatory mediator, as a promoter of angiogenesis in the sponge implant model in mice. Development of blood vessels and blood flow were monitored by use of a 133Xe washout technique. The results showed PAF to have angiogenic activity, which was inhibited by WEB 2086, and the PAF-induced vasculature to have normal pharmacological reactivity.
血管生成伴随着炎症过程和许多其他病理状况。我们在小鼠海绵植入模型中研究了血小板活化因子（PAF）（一种著名的炎症介质）作为血管生成促进剂的作用。通过使用133Xe洗脱技术监测血管的发育和血流情况。结果显示PAF具有血管生成活性，这种活性被WEB 2086抑制，并且PAF诱导的脉管系统具有正常的药理反应性。
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