Inglot A D, Leszek J, Piasecki E, Sypula A
Laboratory of Virology, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Biol Psychiatry. 1994 Apr 1;35(7):464-73. doi: 10.1016/0006-3223(94)90045-0.
The spontaneous and induced interferon (IFN) production in whole blood cultures was examined in 45 psychiatric inpatients and in 65 normal controls. Among inpatients there were 32 who were chronic schizophrenics (14 women, 18 men) and 13 who were severely depressed (11 women, 2 men). The analysis of the pooled results of assays in the heterogeneous population showed that leukocytes of the psychiatric patients produced significantly lower levels of IFN after stimulation with virus (NDV), lipopolysaccharide (LPS), and IFN spontaneously released without the inducers that control cells. In contrast, there was no difference between the psychiatric patients and controls in IFN response to phytohemagglutinin and phorbol myristate acetate (PHA + PMA). The results apparently confirmed observations made by Moises et al (1985) and Katila et al (1989). We have also tested our hypothesis that the statistics may mask the individual pattern of IFN response related to the specific psychiatric diagnosis, however. In fact, in the group of chronic schizophrenics we have found either high or low responders to all IFN inducers (NDV, PHA + PMA and LPS). Furthermore, the patients with high IFN response had dominant positive symptoms of schizophrenia (delusions, hallucinations, bizarre behavior and thought disorder). Whereas, in the patients with low IFN response the negative symptoms prevailed (asociality or withdrawal, flat affect, attention impairment, abolition or apathy). In plasma samples of schizophrenics, factors were detected that transferred a hypersensitivity to the IFN inducers to normal donor leukocytes. For instance, in leukocytes cultured in the presence of plasma from schizophrenics, there were 71% of high IFN responders after stimulation with NDV, versus 26% of high IFN responders in the presence of plasma from normal controls. We suggest that the factors may belong to the class of opioid peptides, which interact with the production of cytokines including IFNs.
对45名精神科住院患者和65名正常对照者的全血培养物中自发和诱导的干扰素（IFN）产生情况进行了检测。住院患者中有32名慢性精神分裂症患者（14名女性，18名男性）和13名重度抑郁症患者（11名女性，2名男性）。对异质人群检测结果的汇总分析表明，精神科患者的白细胞在受到病毒（新城疫病毒，NDV）、脂多糖（LPS）刺激后产生的IFN水平显著低于对照细胞，且在无诱导剂情况下自发释放的IFN也较低。相比之下，精神科患者和对照者对植物血凝素和佛波酯肉豆蔻酸酯（PHA + PMA）的IFN反应没有差异。这些结果显然证实了莫伊塞斯等人（1985年）和卡蒂拉等人（1989年）的观察结果。然而，我们也检验了我们的假设，即统计数据可能掩盖了与特定精神科诊断相关的IFN反应个体模式。事实上，在慢性精神分裂症患者组中，我们发现对所有IFN诱导剂（NDV、PHA + PMA和LPS）都有高反应者或低反应者。此外，IFN反应高的患者具有精神分裂症的显性阳性症状（妄想、幻觉、怪异行为和思维障碍）。而IFN反应低的患者则以阴性症状为主（社交障碍或退缩、情感平淡、注意力受损、无反应或冷漠）。在精神分裂症患者的血浆样本中，检测到了能将对IFN诱导剂的超敏反应转移至正常供体白细胞的因子。例如，在用精神分裂症患者血浆培养的白细胞中，受到NDV刺激后有71%的高IFN反应者，而在正常对照者血浆存在的情况下，高IFN反应者为26%。我们认为这些因子可能属于阿片肽类，它们与包括IFN在内的细胞因子的产生相互作用。
