Barrow C J, Sun H H
Natural Products Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355.
J Nat Prod. 1994 Apr;57(4):471-6. doi: 10.1021/np50106a005.
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.
一种新型P物质抑制剂——螺喹唑啉[1]，是从最初从土壤中获得的黄曲霉菌中分离得到的。通过光谱数据分析确定了1的结构，结果表明1含有一个新的含螺碳中心的碳骨架。从同一培养提取物中还分离出了新的天然产物苯并二氮杂卓二酮[3]以及已知化合物酰基阿佐萘宁[4]、N-苯甲酰基-L-苯丙氨醇和七种二酮哌嗪。
