Ahern G L, Labiner D M, Hutzler R, Osburn C, Talwar D, Herring A M, Tackenberg J N, Weinand M E, Oommen K J
Behavioral Neurology Unit, University of Arizona Health Sciences Center, Tucson 85724.
Electroencephalogr Clin Neurophysiol. 1994 Jul;91(1):21-32. doi: 10.1016/0013-4694(94)90015-9.
Thirty-seven subjects underwent bilateral internal carotid artery injections of amobarbital prior to surgery for intractable epilepsy. The electroencephalogram (EEG) of these patients was continuously monitored during these 74 procedures and was later subjected to quantitative analysis. Topographic mapping of these data suggested that the areas of inactivation were largely restricted to the anterior 2/3 of the hemisphere injected, corresponding to the vascular distributions of the anterior and middle cerebral arteries. Graphical representation of the data demonstrated that delta and theta band activity peaked in the first 2 min post injection and decreased gradually thereafter, becoming stable at around 12 min post injection. Examination of the alpha, beta 1, and beta 2 bands suggested that activity increased and decreased more gradually than that for delta and theta, with perhaps a longer latency. Although EEG changes were most prominent in the anterior 2/3 of the inactivated hemisphere, similar (though smaller) changes were also observed in both ipsilateral and contralateral zones thought to be outside of the vascular distribution of the internal carotid artery.
37名受试者在接受顽固性癫痫手术前接受了双侧颈内动脉注射异戊巴比妥。在这74次操作过程中，对这些患者的脑电图（EEG）进行了持续监测，随后进行了定量分析。这些数据的地形图显示，失活区域主要局限于注射半球的前2/3，对应于大脑前动脉和大脑中动脉的血管分布。数据的图形表示表明，δ波和θ波活动在注射后最初2分钟达到峰值，此后逐渐下降，在注射后约12分钟趋于稳定。对α波、β1波和β2波的检查表明，其活动的增减比δ波和θ波更为缓慢，潜伏期可能更长。尽管EEG变化在失活半球的前2/3最为明显，但在同侧和对侧被认为在颈内动脉血管分布之外的区域也观察到了类似（尽管较小）的变化。
