McRitchie D A, Törk I
School of Anatomy, University of New South Wales, Kensington, Sydney, Australia.
J Comp Neurol. 1994 May 1;343(1):83-101. doi: 10.1002/cne.903430107.
The anatomical distribution of substance P-like immunoreactivity across the subnuclear divisions of the nucleus of the solitary tract has been examined in the human medulla oblongata. A differential distribution of neurons, fibres, and terminals was observed throughout the ten subnuclear divisions of this nucleus. Substance P-like immunoreactive neurons were observed most frequently in the nucleus gelatinosus, with moderate numbers in the medial, intermediate subnuclei and very few in the commissural, ventral, dorsal, and dorsolateral subnuclei. The paracommissural, ventrolateral, and interstitial subnuclei did not contain substance P-like-immunoreactive neurons. These neurons were typically bipolar and moderate-sized to large, except for the neurons in the nucleus gelatinosus, which were substantially smaller. The highest densities of fibres and terminals were observed in the gelatinosus, medial, and intermediate nuclei, with moderate densities in the paracommissural and dorsal subnuclei. Sparse substance P-like-immunoreactive fibres and terminals were seen in the ventral and interstitial nuclei as well as within the solitary tract. The dorsolateral nucleus was characterized by a light distribution of fibres and terminals, except for a dense aggregation along its lateralmost border. A prominent innervation of pigmented neurons by substance P-like-immunoreactive terminals and fibres was also observed in the dorsolateral nucleus. The results reveal that the subnuclear complexity of the nucleus of the solitary tract is richly reflected by its differential pattern of substance P-like-immunoreactive structures.
在人类延髓中，已对孤束核各亚核分区中P物质样免疫反应性的解剖分布进行了研究。在该核的十个亚核分区中均观察到神经元、纤维和终末的差异分布。P物质样免疫反应性神经元最常见于胶状核，中等数量见于内侧、中间亚核，而在连合、腹侧、背侧和背外侧亚核中则非常少见。连合旁、腹外侧和间质亚核不含P物质样免疫反应性神经元。这些神经元通常为双极型，大小中等至较大，但胶状核中的神经元明显较小。在胶状核、内侧和中间核中观察到纤维和终末的密度最高，在连合旁和背侧亚核中密度中等。在腹侧和间质核以及孤束内可见稀疏的P物质样免疫反应性纤维和终末。背外侧核的特征是纤维和终末分布较淡，但其最外侧边界有密集聚集。在背外侧核中还观察到P物质样免疫反应性终末和纤维对色素神经元的显著支配。结果表明，孤束核的亚核复杂性通过其P物质样免疫反应性结构的差异模式得到了充分体现。
