Weglicki W B, Phillips T M, Mak I T, Cassidy M M, Dickens B F, Stafford R, Kramer J H
Department of Physiology, George Washington University Medical Center, Washington, D.C. 20037.
Ann N Y Acad Sci. 1994 Jun 17;723:246-57.
In summary, hypomagnesemia enhances reperfusion injury. We postulate that neurogenic inflammation, which occurs very early during hypomagnesemia, predisposes the myocardium to reperfusion injury by depleting endogenous antioxidants and recruiting inflammatory cells, which can participate in enhanced free radical production during postischemic reperfusion. Vitamin E supplements can prevent the occurrence of this enhanced injury possibly through the restoration of endogenous antioxidant defenses.
