Kharb S, Singh V
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana.
J Assoc Physicians India. 2000 May;48(5):484-5.
Oxidative injury and magnesium deficiency may accompany cardiovascular disease states and the study was planned to find out whether magnesium deficiency promotes oxidative injury.
Serum malonaldehyde (MDA), magnesium, vitamin E and total glutathione levels (GSH) were estimated in 22 patients with acute myocardial infarction and 15 healthy controls.
Low levels of Mg, GSH, vitamin E and elevated levels of MDA were observed in patients of acute myocardial infarction. Statistically significant correlations were observed between Mg and MDA, MDA and GSH, Mg and vitamin E.
Our findings suggest that Mg deficiency can potentiate oxidative injury to post ischaemic myocardium and that antioxidants may have a role in protection against the prooxidant influence(s) of Mg deficiency.
氧化损伤和镁缺乏可能伴随心血管疾病状态，本研究旨在探究镁缺乏是否会促进氧化损伤。
对22例急性心肌梗死患者和15名健康对照者测定血清丙二醛（MDA）、镁、维生素E和总谷胱甘肽水平（GSH）。
急性心肌梗死患者中观察到镁、谷胱甘肽、维生素E水平较低，丙二醛水平升高。镁与丙二醛、丙二醛与谷胱甘肽、镁与维生素E之间存在统计学显著相关性。
我们的研究结果表明，镁缺乏可增强对缺血后心肌的氧化损伤，抗氧化剂可能在抵御镁缺乏的促氧化影响方面发挥作用。
