总结：RNA的修饰核苷。
Summary: the modified nucleosides of RNA.
作者信息
Limbach P A, Crain P F, McCloskey J A
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
出版信息
Nucleic Acids Res. 1994 Jun 25;22(12):2183-96. doi: 10.1093/nar/22.12.2183.
Abstract
A comprehensive listing is made of posttranscriptionally modified nucleosides from RNA reported in the literature through mid-1994. Included are chemical structures, common names, symbols, Chemical Abstracts registry numbers (for ribonucleoside and corresponding base), Chemical Abstracts Index Name, phylogenetic sources, and initial literature citations for structural characterization or occurrence, and for chemical synthesis. The listing is categorized by type of RNA: tRNA, rRNA, mRNA, snRNA, and other RNAs. A total of 93 different modified nucleosides have been reported in RNA, with the largest number and greatest structural diversity in tRNA, 79; and 28 in rRNA, 12 in mRNA, 11 in snRNA and 3 in other small RNAs.
摘要
本文全面列举了截至1994年年中文献报道的RNA转录后修饰核苷。内容包括化学结构、通用名称、符号、化学文摘登记号（针对核糖核苷及相应碱基）、化学文摘索引名称、系统发生来源，以及结构表征或存在情况、化学合成的初始文献引用。该列表按RNA类型分类：tRNA、rRNA、mRNA、snRNA和其他RNA。RNA中共报道了93种不同的修饰核苷，其中tRNA中的数量最多且结构多样性最大，有79种；rRNA中有28种，mRNA中有12种，snRNA中有11种，其他小RNA中有3种。
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本文引用的文献
1
Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil.大肠杆菌转移 RNA 中的硫碱基：2-硫胞嘧啶和 5-甲氨甲基-2-硫尿嘧啶。
Science. 1968 Sep 13;161(3846):1146-7. doi: 10.1126/science.161.3846.1146.
2
Classification of methanogenic bacteria by 16S ribosomal RNA characterization.通过16S核糖体RNA特征对产甲烷菌进行分类。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4537-41. doi: 10.1073/pnas.74.10.4537.
3
Methylation studies on various uracil derivatives and on an isomer of uridine isolated from ribonucleic acids.对各种尿嘧啶衍生物以及从核糖核酸中分离出的尿苷异构体的甲基化研究。
Biochim Biophys Acta. 1959 Apr;32:406-12. doi: 10.1016/0006-3002(59)90613-4.
4
PURINE NUCLEOSIDES. X. THE SYNTHESIS OF CERTAIN NATURALLY OCCURRING 2-SUBSTITUTED AMINO-9-BETA-D-RIBOFURANOSYLPURIN-6(1H)-ONES (N2-SUBSTITUTED GUANOSINES).嘌呤核苷。X. 某些天然存在的2-取代氨基-9-β-D-呋喃核糖基嘌呤-6(1H)-酮（N2-取代鸟苷）的合成
J Am Chem Soc. 1965 Aug 20;87:3752-9. doi: 10.1021/ja01094a037.
5
A GENERAL PROCEDURE FOR THE ISOLATION OF "MINOR" NUCLEOSIDES FROM RIBONUCLEIC ACID HYDROLYSATES.从核糖核酸水解物中分离“次要”核苷的一般方法。
Biochemistry. 1965 Apr;4:661-70. doi: 10.1021/bi00880a008.
6
THE DIRECT PREPARATION OF 2'-O-METHYLADENOSINE FROM ADENOSINE.由腺苷直接制备2'-O-甲基腺苷
J Am Chem Soc. 1965 Mar 5;87:1145-6. doi: 10.1021/ja01083a045.
7
THE PRESENCE OF 5,6-DIHYDROURIDYLIC ACID IN YEAST "SOLUBLE" RIBONUCLEIC ACID.酵母“可溶性”核糖核酸中5,6 - 二氢尿苷酸的存在
Biochem Biophys Res Commun. 1965 Jan 18;18:153-7. doi: 10.1016/0006-291x(65)90732-1.
8
THE OCCURRENCE OF METHYLATED BASES IN RIBOSOMAL RIBONUCLEIC ACID OF ESCHERICHIA COLI K12 W-6.大肠杆菌K12 W-6核糖体核糖核酸中甲基化碱基的出现情况
J Biol Chem. 1964 Oct;239:3457-61.
9
ON THE 2'-O-METHYLRIBONUCLEOSIDE CONTENT OF RIBONUCLEIC ACIDS.论核糖核酸的2'-O-甲基核糖核苷含量。
Biochemistry. 1964 Jul;3:876-80. doi: 10.1021/bi00895a001.
10
THE ALKALI-STABLE DINUCLEOTIDE SEQUENCES IN 18S+28S RIBONUCLEATES FROM WHEAT GERM.小麦胚芽18S + 28S核糖核酸中的碱稳定二核苷酸序列。
Can J Biochem. 1964 Jul;42:1011-21. doi: 10.1139/o64-112.
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