Krishna A G, Balasubramanian D, Ganesh K N
Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Biochem Biophys Res Commun. 1994 Jul 15;202(1):204-10. doi: 10.1006/bbrc.1994.1913.
alpha(1,4) glucopyranose chains (dextrins) are shown to interact with DNA via hydrophobic interactions from the minor groove side, while alpha(1,6) dextrans do not bind DNA. The observed specific alpha(1,4) linked sugar-DNA interactions may have importance in recognition of DNA by ene-diyne class of antibiotics via their saccharide units which have mostly alpha(1,4) linkages.
α(1,4)吡喃葡萄糖链（糊精）显示通过来自小沟侧的疏水相互作用与DNA相互作用，而α(1,6)葡聚糖不结合DNA。观察到的特定α(1,4)连接的糖-DNA相互作用可能在烯二炔类抗生素通过其大多具有α(1,4)连接的糖单元识别DNA方面具有重要意义。
