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巨噬细胞RAW 264.7对一氧化氮合酶抑制剂的摄取。

Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells.

作者信息

Schmidt K, Klatt P, Mayer B

机构信息

Institut für Pharmakologie und Toxikologie, Karl-Franzens-Universität Graz, Austria.

出版信息

Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):313-6. doi: 10.1042/bj3010313.

DOI:10.1042/bj3010313
PMID:7519006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137080/
Abstract

Uptake of the nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y+) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.

摘要

巨噬细胞对一氧化氮合酶抑制剂NG-甲基-L-精氨酸（L-NMA）和NG-硝基-L-精氨酸（L-NNA）的摄取由两种不同机制介导。用细胞因子激活细胞会导致L-NMA摄取上调，但不影响L-NNA转运。对转运位点的表征显示，L-NMA的摄取由阳离子氨基酸转运体（y+系统）介导，而中性氨基酸转运体（L系统）负责L-NNA的摄取。

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本文引用的文献

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Characterization of system L and system y+ amino acid transport activity in cultured vascular smooth muscle cells.培养的血管平滑肌细胞中L系统和y+系统氨基酸转运活性的特征分析。
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NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase.NG-甲基-L-精氨酸作为一氧化氮合酶的替代底物和基于机制的抑制剂发挥作用。
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Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.参与一氧化氮合酶抑制剂作用的内皮细胞氨基酸转运系统的特性分析
Mol Pharmacol. 1993 Sep;44(3):615-21.
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Transport of L-[3H]arginine in cultured neurons: characteristics and inhibition by nitric oxide synthase inhibitors.培养神经元中L-[3H]精氨酸的转运：特性及一氧化氮合酶抑制剂的抑制作用
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