巨噬细胞RAW 264.7对一氧化氮合酶抑制剂的摄取。
Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells.
作者信息
Schmidt K, Klatt P, Mayer B
机构信息
Institut für Pharmakologie und Toxikologie, Karl-Franzens-Universität Graz, Austria.
出版信息
Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):313-6. doi: 10.1042/bj3010313.
Abstract
Uptake of the nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y+) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.
摘要
巨噬细胞对一氧化氮合酶抑制剂NG-甲基-L-精氨酸（L-NMA）和NG-硝基-L-精氨酸（L-NNA）的摄取由两种不同机制介导。用细胞因子激活细胞会导致L-NMA摄取上调，但不影响L-NNA转运。对转运位点的表征显示，L-NMA的摄取由阳离子氨基酸转运体（y+系统）介导，而中性氨基酸转运体（L系统）负责L-NNA的摄取。
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