Nikoskelainen J, Stevens D A, Neel E U, Isenberg R A, Miller R G, Halpern J W, Gelpi A P
IARC Sci Publ (1971). 1978(24 Pt 2):699-709.
Lymphocytes of patients with infectious mononucleosis (IM), EBV sero-positive subjects, patients with viral infections other than EBV, and EBV sero-negative subjects were tested for phytohaemagglutinin (PHA)-induced and spontaneous transformation in vitro. Lymphocytes of EBV sero-positive healthy subjects, tested in autologous serum, have higher spontaneous transformation than those of EBV sero-negative subjects. IM patients, in the acute phase of illness, have depressed spontaneous lymphocyte transformation, independent of serum factors. Serum factors are present in acute IM that depress spontaneous transformation further, and to a lesser extent depress reactivity to PHA. By the time the IM patients had recovered, greater than 9 weeks after onset of illness, the defects observed had disappeared.
对传染性单核细胞增多症（IM）患者、EBV血清学阳性受试者、除EBV外的病毒感染患者以及EBV血清学阴性受试者的淋巴细胞进行体外植物血凝素（PHA）诱导的转化和自发转化检测。在自身血清中检测的EBV血清学阳性健康受试者的淋巴细胞，其自发转化高于EBV血清学阴性受试者。处于疾病急性期的IM患者，其自发淋巴细胞转化受到抑制，与血清因素无关。急性IM患者血清中存在进一步抑制自发转化且在较小程度上抑制对PHA反应性的血清因子。到IM患者康复时，即发病后9周以上，观察到的缺陷已消失。
