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[睾丸I期恶性非精原细胞瘤肿瘤的治疗,无需系统性腰主动脉淋巴结清扫。一项始于20年前的研究结果。关于21例病例]

[The treatment of stage I malignant non-seminoma tumors of the testis without systematic lumbo-aortic dissection. Results of a study begun 20 years ago. Apropos of 21 cases].

作者信息

Aubert J, Bon D, Dore B, Irani J

机构信息

Service d'Urologie, CHU de Poitiers.

出版信息

Prog Urol. 1994 Jun;4(3):349-56.

PMID:7519099
Abstract

Over a 20-year period (1971-1991), the authors have treated 75 malignant testicular tumours, corresponding to 33 seminomas and 42 nonseminomatous tumours. The latter group included 23 stage I tumours according to Peckham's classification. The authors studied the therapeutic modalities of 21 of these patgients (2 non-protocol patients excluded) treated without lumboaortic lymph node dissection. Adjuvant therapy consisted of radiotherapy alone (2 cases), radiotherapy and chemotherapy (5 cases) and chemotherapy alone (14 cases). All patients are alive in complete remission (100%) with a follow-up of at least 24 months (range: 31-222 months, mean survival: 102.2 months). In line with what they already believed in 1971, the authors consider that systematic lumboaortic lymph node dissection is not essential in the treatment of stage I nonseminomatous testicular tumours, but propose systematic adjuvant therapy. Chemotherapy (PVB or, preferably, PEB) provides a guarantee of security and good acceptability.

摘要

在20年期间(1971 - 1991年),作者治疗了75例睾丸恶性肿瘤,其中33例为精原细胞瘤,42例为非精原细胞瘤。根据佩卡姆分类,后一组包括23例I期肿瘤。作者研究了其中21例(排除2例非方案患者)未进行腰主动脉淋巴结清扫治疗的患者的治疗方式。辅助治疗包括单纯放疗(2例)、放疗和化疗(5例)以及单纯化疗(14例)。所有患者均存活且完全缓解(100%),随访至少24个月(范围:31 - 222个月,平均生存期:102.2个月)。与他们在1971年就已持有的观点一致,作者认为对于I期非精原细胞瘤性睾丸肿瘤的治疗,系统性腰主动脉淋巴结清扫并非必需,但建议进行系统性辅助治疗。化疗(PVB或更佳的PEB)提供了安全性保证且耐受性良好。

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