Ouvina G B, Lemberg A, Bengochea L A
Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires.
Arch Int Physiol Biochim Biophys. 1994 Mar-Apr;102(2):121-3. doi: 10.3109/13813459408996118.
Liver microsomal glucuronidation of acetaminophen, chloramphenicol, salicylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats showed a decrease of 31% for p-nitrophenol glucuronidation; salicylic acid glucuronidation increased 281%; acetaminophen glucuronidation increased 38% while morphine, chloramphenicol and lorazepam values were similar to controls. We concluded that cholestasis produces non predictable changes on liver drug glucuronidation pathways.
在8天胆管结扎大鼠中测定了对乙酰氨基酚、氯霉素、水杨酸、劳拉西泮、对硝基苯酚和吗啡的肝微粒体葡萄糖醛酸化作用。与正常大鼠相比，胆汁淤积大鼠的对硝基苯酚葡萄糖醛酸化作用降低了31%；水杨酸葡萄糖醛酸化作用增加了281%；对乙酰氨基酚葡萄糖醛酸化作用增加了38%，而吗啡、氯霉素和劳拉西泮的值与对照组相似。我们得出结论，胆汁淤积会对肝脏药物葡萄糖醛酸化途径产生不可预测的变化。
