Kaur R, Parshad V R
Department of Zoology, Punjab Agricultural University, Ludhiana, India.
Mutat Res. 1994 Aug 1;309(1):29-35. doi: 10.1016/0027-5107(94)90039-6.
Ingestion of 2 ppm and 4 ppm selenium in the diet by the house rat, Rattus rattus, for 5 weeks caused a dose-dependent reduction in its body weight, testicular and cauda epididymidis weights, concentration, motility and percentage of live spermatozoa with a simultaneous increase in the percentage of their abnormal forms. Compared to 1.39% abnormal spermatozoa in cauda epididymidis in untreated control rats, 3.89% and 24.64% abnormal spermatozoa were observed in rats with 2 ppm and 4 ppm dietary selenium respectively. Ingestion of 4 ppm selenium had no significant effect on abnormalities of the head and neck regions but abnormalities of the midpiece region and multiple abnormalities increased significantly. Analysis of the various stages of differentiation of spermatids in the testis has revealed that with 4 ppm dietary selenium, the abnormalities are induced mainly in the midpiece region of the flagellum which is a site of energy production.
家鼠（褐家鼠）连续5周摄入饮食中含2 ppm和4 ppm硒后，体重、睾丸和附睾尾部重量、精子浓度、活力及活精子百分比呈剂量依赖性降低，同时精子异常形态百分比增加。与未处理的对照大鼠附睾尾部1.39%的异常精子相比，饮食中含2 ppm和4 ppm硒的大鼠附睾尾部异常精子分别为3.89%和24.64%。摄入4 ppm硒对头部和颈部区域的异常无显著影响，但中段区域异常和多种异常显著增加。对睾丸中生精细胞不同分化阶段的分析表明，饮食中含4 ppm硒时，异常主要发生在鞭毛的中段区域，该区域是能量产生部位。
