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通过谷胱甘肽耗竭诱导的氧化还原变化抑制人髓系细胞系的分化。

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.

作者信息

Esposito F, Agosti V, Morrone G, Morra F, Cuomo C, Russo T, Venuta S, Cimino F

机构信息

Dipartimento di Biochemica e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Italy.

出版信息

Biochem J. 1994 Aug 1;301 ( Pt 3)(Pt 3):649-53. doi: 10.1042/bj3010649.

DOI:10.1042/bj3010649
PMID:7519845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137037/
Abstract

We have investigated the effect of redox changes in vivo on the differentiation of two human myeloid cell lines, HL-60 and KG-1. The glutathione-depleting agent diethyl maleate (DEM) prevented the development of differentiated features in response to phorbol esters, including adherence of the cells to plastic surfaces and repression of the myeloperoxidase and CD34 genes. Moreover, DEM abolished phorbol 12-myristate 13-acetate-induced activation of the transcription factors AP-1 and Egr-1, suggesting that inhibition of differentiation may be due, at least in part, to redox modifications of these proteins.

摘要

我们研究了体内氧化还原变化对两种人类髓系细胞系HL-60和KG-1分化的影响。谷胱甘肽消耗剂马来酸二乙酯（DEM）可防止细胞因佛波酯而出现分化特征，包括细胞黏附于塑料表面以及髓过氧化物酶和CD34基因的表达受抑制。此外，DEM消除了佛波醇12-肉豆蔻酸酯13-乙酸酯诱导的转录因子AP-1和Egr-1的激活，这表明分化抑制可能至少部分归因于这些蛋白质的氧化还原修饰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/c746cdc8bd5e/biochemj00082-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/c98cdece4eec/biochemj00082-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/7120dcc3cea1/biochemj00082-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/4d142a96fe79/biochemj00082-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/c746cdc8bd5e/biochemj00082-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/c98cdece4eec/biochemj00082-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/7120dcc3cea1/biochemj00082-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/4d142a96fe79/biochemj00082-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392e/1137037/c746cdc8bd5e/biochemj00082-0036-a.jpg

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