在患有类风湿性关节炎的西非人群中，针对与类风湿性关节炎核抗原主要表位相对应的合成肽P62的抗体。

Antibodies to synthetic peptide P62 corresponding to the major epitope of rheumatoid arthritis nuclear antigen in a west African population with rheumatoid arthritis.

作者信息

Adebajo A O, Williams D G, Hazleman B L, Venables P J

机构信息

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge.

出版信息

Br J Rheumatol. 1994 Aug;33(8):718-20. doi: 10.1093/rheumatology/33.8.718.

DOI:10.1093/rheumatology/33.8.718

PMID:7519956

Abstract

Using a synthetic peptide (P62) we have investigated antibodies to rheumatoid arthritis nuclear antigen (RANA) in 58 West African patients with RA, 51 with malaria, 111 with tuberculosis (TB) and 166 healthy controls by ELISA using a synthetic peptide (P62). As in Western populations the RA sera showed significantly increased levels of anti-P62 antibodies though in our study the mean titres were only elevated twofold above the controls. The levels in malaria and TB were normal. Our data extend previous work by showing that raised anti-P62 antibodies is a consistent finding in RA world-wide including indigenous West African patients.

摘要

我们使用一种合成肽（P62），通过酶联免疫吸附测定法（ELISA），对58名患有类风湿性关节炎（RA）的西非患者、51名患有疟疾的患者、111名患有结核病（TB）的患者以及166名健康对照者，检测了针对类风湿性关节炎核抗原（RANA）的抗体。与西方人群一样，RA患者血清中抗P62抗体水平显著升高，不过在我们的研究中，平均滴度仅比对照组高两倍。疟疾和结核病患者的抗体水平正常。我们的数据拓展了之前的研究工作，表明抗P62抗体升高在包括西非本土患者在内的全球范围内的RA患者中是一个一致的发现。