原发性皮下平滑肌肉瘤表现出波形蛋白和结蛋白免疫表型呈阳性的特征。
Primary subcutaneous leiomyosarcoma exhibiting the characteristic immunophenotype positive for vimentin and desmin.
作者信息
Boehncke W H, Schwenck K, Sterry W, Kaufmann R
机构信息
Department of Dermatology, University of Ulm, Germany.
出版信息
J Dermatol Surg Oncol. 1994 Aug;20(8):541-3. doi: 10.1111/j.1524-4725.1994.tb00140.x.
BACKGROUND
Primary subcutaneous leiomyosarcoma is a rare neoplasm composed of plump, elongated spindle cells arranged in interweaving fascicles.
OBJECTIVE
Differential diagnosis might be facilitated by the use of immunohistochemistry.
METHODS
A case of subcutaneous leiomyosarcoma was investigated histologically on paraffin-embedded tissue and immunohistochemistry was performed following standard procedures.
RESULTS
The case reported exhibited light microscopic features and an immunophenotype characteristic of leiomyosarcoma. However, the intermediate filament desmin could only be found on a small number of tumor cells.
CONCLUSION
Expression of these markers might vary considerably and immunoperoxidase stainings need to be carefully evaluated. Utilization of several antibodies directed against different desmin epitopes might be advantageous.
背景
原发性皮下平滑肌肉瘤是一种罕见的肿瘤，由排列成交织束状的丰满、细长梭形细胞组成。
目的
免疫组织化学的应用可能有助于鉴别诊断。
方法
对1例皮下平滑肌肉瘤石蜡包埋组织进行组织学研究，并按照标准程序进行免疫组织化学检测。
结果
报告的病例显示出平滑肌肉瘤的光镜特征和免疫表型。然而，中间丝结蛋白仅在少数肿瘤细胞中发现。
结论
这些标志物的表达可能有很大差异，免疫过氧化物酶染色需要仔细评估。使用几种针对不同结蛋白表位的抗体可能会有帮助。
Zotero 插件