Székely E, Madaras L, Kulka J, Járay B, Nagy L
Semmelweis University, 2nd Department of Pathology Ullôi út 93, Budapest, H-1091, Hungary.
Pathol Oncol Res. 2001;7(2):151-3. doi: 10.1007/BF03032583.
Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed.
乳腺平滑肌肉瘤是罕见肿瘤。迄今为止，文献报道的此类病例不足15例。本文作者描述了一例女性乳腺平滑肌肉瘤病例，表现为质地坚硬的分叶状肿块，影像学上类似叶状肿瘤。通过细针穿刺活检，涂片上可见散在的形态可疑的恶性细胞，初步诊断为低分化浸润性乳腺癌。乳房切除标本中有一个分叶状肿块，显微镜下显示为部分上皮样梭形细胞瘤，对波形蛋白、结蛋白、平滑肌肌动蛋白抗体呈免疫反应，对上皮标志物、激素和生长因子受体呈阴性反应。腋窝淋巴结无肿瘤转移。最终诊断为原发性乳腺平滑肌肉瘤。
