Martinerie C, Huff V, Joubert I, Badzioch M, Saunders G, Strong L, Perbal B
Laboratoire d'Oncologie Virale et Moléculaire, Institut Curie, Orsay, France.
Oncogene. 1994 Sep;9(9):2729-32.
We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH is elevated in Wilms tumors containing predominantly stromal elements and is inversely correlated in these tumors to the expression of WT1. Our results suggest that the regulation of IGFII expression by WT1 and increase of novH in Wilms tumors might be interrelated and represent a key element in tumor development in human.
我们已经克隆并测序了nov基因（novH），它是在禽肾母细胞瘤中过度表达的鸡nov原癌基因的同源物。novH基因高度保守，编码一种类似于鸡的假定胰岛素样生长因子结合蛋白。我们报告，相对于自体正常肾脏，novH在主要含有基质成分的肾母细胞瘤中的表达升高，并且在这些肿瘤中与WT1的表达呈负相关。我们的结果表明，WT1对胰岛素样生长因子II（IGFII）表达的调节以及肾母细胞瘤中novH的增加可能相互关联，并且是人类肿瘤发生中的关键因素。
