Daily C A, Laurent S L, Nunley W C
Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte.
Am J Obstet Gynecol. 1994 Aug;171(2):380-3; discussion 383-4. doi: 10.1016/s0002-9378(94)70038-9.
Our purpose was to determine whether serum progesterone, with or without quantitative beta-human chorionic gonadotropin, is predictive of pregnancy outcome within the first 8 weeks of gestation in asymptomatic women.
Asymptomatic patients at < 8 menstrual weeks' gestation were prospectively evaluated. The enrollment protocol included history, physical examination, ultrasonographic confirmation, and blood sample collection for beta-human chorionic gonadotropin and progesterone. The association between progesterone and beta-human chorionic gonadotropin values and pregnancy outcome was determined by logistic regression analysis. A receiver-operator characteristic curve was generated on the basis of the sensitivity and specificity of progesterone results.
Seventy-four patients were evaluated in this study. The mean serum progesterone level for viable pregnancies was 22.1 ng/ml, which was significantly greater than that for the nonviable gestations, 10.1 ng/ml (p < 0.001). A single progesterone level was predictive of pregnancy outcome (p < 0.001). The probability of an abnormal pregnancy outcome with a serum progesterone level < or = 6 ng/ml was 81%. A single beta-human chorionic gonadotropin level did not contribute to the prediction of pregnancy outcome (p = 0.59).
Serum progesterone alone, within the first 8 weeks of gestation, is predictive of pregnancy outcome.
我们的目的是确定血清孕酮（无论是否联合定量β-人绒毛膜促性腺激素）能否预测无症状女性妊娠8周内的妊娠结局。
对妊娠8周内的无症状患者进行前瞻性评估。入组方案包括病史、体格检查、超声确认以及采集血样检测β-人绒毛膜促性腺激素和孕酮。通过逻辑回归分析确定孕酮和β-人绒毛膜促性腺激素值与妊娠结局之间的关联。根据孕酮检测结果的敏感性和特异性绘制受试者操作特征曲线。
本研究共评估了74例患者。存活妊娠的血清孕酮平均水平为22.1 ng/ml，显著高于非存活妊娠的10.1 ng/ml（p < 0.001）。单一孕酮水平可预测妊娠结局（p < 0.001）。血清孕酮水平≤6 ng/ml时出现异常妊娠结局的概率为81%。单一β-人绒毛膜促性腺激素水平对妊娠结局的预测无作用（p = 0.59）。
妊娠8周内，仅血清孕酮即可预测妊娠结局。
