Hoshino K, Kawaguchi H, Unate H, Nitta K, Fukui H, Ikeda M, Tsujitani S
Dept. of Surgery, Yonago National Hospital, Japan.
Gan To Kagaku Ryoho. 1996 Aug;23(9):1197-200.
We reported our experience with a case of AFP producing gastric cancer with liver metastasis successfully treated with FEP therapy by continuous daily venous infusion of 5-FU and low-dose CDDP. A 59-year-old male was diagnosed with liver metastasis 2 months after partial gastrectomy of gastric cancer and then admitted. The patient received five courses of 24-hour continuous infusion of CDDP (5 mg/day, on day 1, 2, 3, 4, 5) and 5-FU (250 mg/day, on day 1, 3, 5) and bolus infusion of Epirubicin (10 mg/day, on day 3). No remarkable side effect was encountered. Complete response at the liver metastasis was observed by CT scan. Serum AFP level was down from 614 ng/ml to the normal range of 0.5 ng/ml after the therapy. The patient has been well for 10 months with complete remission.
我们报告了1例经每日持续静脉输注5-氟尿嘧啶（5-FU）和低剂量顺铂（CDDP）的FEP疗法成功治疗的伴有肝转移的甲胎蛋白（AFP）产生型胃癌病例的经验。一名59岁男性在胃癌部分切除术后2个月被诊断出肝转移，随后入院。患者接受了五个疗程的治疗，其中CDDP进行24小时持续输注（5毫克/天，第1、2、3、4、5天），5-FU（250毫克/天，第1、3、5天），表柔比星进行大剂量输注（10毫克/天，第3天）。未出现明显副作用。通过CT扫描观察到肝转移灶完全缓解。治疗后血清AFP水平从614纳克/毫升降至正常范围0.5纳克/毫升。患者已完全缓解并健康状况良好达10个月。
