Jutila M A
Veterinary Molecular Biology Laboratory, Montana State University, Bozeman 59717.
Clin Transplant. 1994 Jun;8(3 Pt 2):304-7.
The recruitment and activation of lymphoid effector cells into grafted tissue is central to the chronic rejection process. The endothelial cells lining inflamed vessels appear to be important in initiating and perpetuating these events through their expression of adhesion proteins for circulating leukocytes, as well as through their production of cytokines and chemokines to attract leukocytes into the inflamed tissues and to activate effector functions. Described here is our current understanding of the role of the vascular endothelium in leukocyte recruitment into inflamed tissues. A model of leukocyte-endothelial cell interactions is outlined.
淋巴细胞效应细胞募集并激活进入移植组织是慢性排斥反应过程的核心。炎症血管内衬的内皮细胞通过表达循环白细胞的黏附蛋白，以及通过产生细胞因子和趋化因子以吸引白细胞进入炎症组织并激活效应功能，在启动和维持这些事件中似乎起着重要作用。本文描述了我们目前对血管内皮在白细胞募集进入炎症组织中作用的理解。概述了白细胞与内皮细胞相互作用的模型。
