Whyte A, Haskard D O, Binns R M
Department of Immunology, AFRC Babraham Institute, Cambridge, UK.
Vet Immunol Immunopathol. 1994 May;41(1-2):31-40. doi: 10.1016/0165-2427(94)90055-8.
The 24 h phytohaemagglutinin-induced skin inflammatory site (intradermal and subcutaneous) was studied in inbred MHC-homozygous (SLAb/b) pigs and it was found, by immunohistology, that the predominant lymphocytes in the infiltrate are CD2-CD4-CD8-sIg-T-cells, the Null/gamma delta T-cell family, identified using the monoclonal antibodies (mAbs) MAC320 and MAC319 (which recognises a subset of MAC320+ cells). A large percentage of the infiltrating cells expressed the gamma delta T-cell receptor phenotype identified by binding of the mAb 86D. Fewer CD2+, CD8+ and CD4+ cells were present and surface immunoglobulin positive (sIg+) cells were virtually absent in the infiltrate. Areas of lymphocytic infiltration were associated with endothelial activation as determined by expression of the E-selectin and a ligand for the L-selectin.
对近交系 MHC 纯合子（SLAb/b）猪的 24 小时植物血凝素诱导的皮肤炎症部位（皮内和皮下）进行了研究，通过免疫组织学发现，浸润中的主要淋巴细胞是 CD2-CD4-CD8-sIg-T 细胞，即 Null/γδT 细胞家族，使用单克隆抗体（mAb）MAC320 和 MAC319（识别 MAC320+细胞的一个亚群）进行鉴定。很大比例的浸润细胞表达了通过 mAb 86D 结合鉴定的γδT 细胞受体表型。浸润中存在的 CD2+、CD8+和 CD4+细胞较少，表面免疫球蛋白阳性（sIg+）细胞几乎不存在。通过 E-选择素和 L-选择素配体的表达确定，淋巴细胞浸润区域与内皮细胞活化有关。
