Tyshko N A, Chernushenko E F, Poddubnyĭ A F
Lik Sprava. 1994 Jan(1):47-9.
Similarity of clinical, roentgenological and even morphological features of tuberculosis and sarcoidosis causes difficulties in differential diagnosis. This necessitates searching for new diagnostic criteria. Comparative study of functional state of peripheral blood neutrophils and their reaction to specific antigens (tuberculin and Kveim's reagent) were studied in patients with disseminated tuberculosis and pulmonary sarcoidosis. Tuberculin was demonstrated to exert specific effects only in tuberculous patients. It stimulated migration and increased number of EAC-rosette-forming cells. Specific effects of Kveim's antigen were manifested by considerable increase of E-RFC number and decreased absorptive abilities of phagocytes in patients with sarcoidosis. Differences in effects of tuberculin and Kveim's antigen may be used for differential diagnosis of tuberculosis and sarcoidosis.
肺结核与结节病在临床、放射学甚至形态学特征上的相似性给鉴别诊断带来了困难。这就需要寻找新的诊断标准。对播散性肺结核和肺结节病患者外周血中性粒细胞的功能状态及其对特定抗原（结核菌素和克维姆试剂）的反应进行了比较研究。结果表明，结核菌素仅对结核病患者产生特异性作用。它刺激了EAC玫瑰花结形成细胞的迁移并增加了其数量。克维姆抗原的特异性作用表现为结节病患者的E-RFC数量显著增加，吞噬细胞的吸收能力下降。结核菌素和克维姆抗原作用的差异可用于肺结核与结节病的鉴别诊断。
