[蛋白酶抑制剂作为实验性急性胰腺炎和葡萄球菌感染中的免疫调节剂]

[Protease inhibitors as immunomodulators in experimental acute pancreatitis and staphylococcal infection].

作者信息

Chalyĭ G A, Prokopenko L G, Latysh N A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1993 Jan-Feb(1):62-5.

PMID:7520651

Abstract

The influence of protease-inhibiting preparations on the development of humoral immune response in diseases involving the development of secondary immunodeficiency (experimentally induced acute pancreatitis and staphylococcal infection) has been studied. Five injections of contrycal and epsilon-aminocaproic acid (epsilon-ACA), starting from day 1 after the induction of acute pancreatitis, normalized the immune response induced by sheep red blood cells 24 hours after operation. In staphylococcal infection protease-inhibiting preparations (contrycal, epsilon-ACA, Amben) produced a protective effect, increasing the survival rate and the mean survival time of the animals infected with staphylococci.

摘要

研究了蛋白酶抑制制剂对涉及继发性免疫缺陷发展的疾病（实验性诱导的急性胰腺炎和葡萄球菌感染）中体液免疫反应发展的影响。从急性胰腺炎诱导后的第1天开始，注射5次抑肽酶和ε-氨基己酸（ε-ACA），可使术后24小时绵羊红细胞诱导的免疫反应恢复正常。在葡萄球菌感染中，蛋白酶抑制制剂（抑肽酶、ε-ACA、氨甲环酸）产生了保护作用，提高了感染葡萄球菌动物的存活率和平均存活时间。