Galabov A S, Khristova M L, Uzunov S, Wassilewa L, Bucher D J, Kharitonenkov I G
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Acta Virol. 1994 Feb;38(1):5-10.
Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was found that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to the antiviral compound mopyridone as compared to the mopyridone-sensitive mutant manifested significant changes in the antigenic structure (sites 1A, 2 and 3) of M1 protein. No differences in M1 were found between rimantadine-resistant and rimantadine-sensitive mutants of influenza virus A(H3N2).
在固相酶联免疫吸附测定中使用14种单克隆抗体（MoAbs）发现，与对吡莫地酮敏感的突变体相比，抗抗病毒化合物吡莫地酮的甲型流感病毒A/香港/1/68（H3N2）突变体在M1蛋白的抗原结构（位点1A、2和3）上表现出显著变化。在甲型流感病毒A（H3N2）的金刚烷胺抗性和金刚烷胺敏感突变体之间未发现M1有差异。
