Kiselev O I, Mishin V P, Eroshkin V I, Kozeletskaia K N, Usova E V, Rudenko V I, Chupakhin O N
Mol Biol (Mosk). 1994 Sep-Oct;28(5):1009-13.
Studies of the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. The influence of aminoacid substitutions in the M2 protein on its secondary structure in the membrane and its role in resistance development was shown.
对甲型流感病毒对药物（金刚乙胺、地替福林、金刚烷胺）耐药性的分子层面研究，有助于有目的地设计具有广谱抗病毒活性且不会引发耐药性的新化合物。在这项研究中，将对金刚乙胺和地替福林耐药的甲型流感病毒列宁格勒/156/83（H3N2）株的核苷酸序列与A/维多利亚/35/72株的核苷酸序列进行了比较。研究表明，M2蛋白中的氨基酸取代对其在膜中的二级结构的影响及其在耐药性产生中的作用。
