子宫恶性肿瘤患者不同细胞角蛋白血清水平的测定。

Determination of serum levels of different cytokeratins in patients with uterine malignancies.

作者信息

Ferdeghini M, Gadducci A, Prontera C, Castellani C, Annicchiarico C, Gagetti O, Facchini V, Bianchi R

机构信息

Istituto di Medicina Nucleare, Università di Pisa, Italy.

出版信息

Anticancer Res. 1994 May-Jun;14(3B):1393-7.

PMID:7520682

Abstract

Tissue polypeptide antigen (TPA), TPS, Cyfra 21-1, Cytokeratins 8-18 (CTKRS 8-18), SCC and CA 125 were measured in blood samples drawn at diagnosis from 43 patients with endometrial cancer, 47 with cervical cancer, 11 with cervical intraepithelial neoplasia (CIN), and 236 with benign uterine disease as controls. The cut-off values for all antigens were chosen at the 95th percentile of the standard Gaussian variate of controls; these limits were 98 U/L for TPA, 127 U/L for TPS, 1.6 ng/mL for Cyfra 21-1, 1.2 ng/mL for CTKRS 8-18, 48 U/mL for CA 125, and 2.8 ng/mL for SCC. TPA had the same sensitivity as SCC for squamous cell carcinoma of the cervix (42%) and a higher sensitivity than CA 125 for endometrial cancer (40% vs 12% respectively). TPA was more sensitive than TPS for both cervical (40% vs 13%) and endometrial cancer (40% vs 21%). TPA and SCC had a higher sensitivity than Cyfra 21-1 (34%) and CTKRS 8-18 (27%) for squamous cell carcinoma of the cervix. In conclusion, as for soluble cytokeratin fragments, the serum TPA seems to be the most reliable marker for the management of cervical and endometrial cancer.

摘要

对43例子宫内膜癌患者、47例宫颈癌患者、11例宫颈上皮内瘤变（CIN）患者以及236例患有良性子宫疾病的对照者在确诊时采集的血样进行组织多肽抗原（TPA）、TPS、细胞角蛋白片段21-1（Cyfra 21-1）、细胞角蛋白8-18（CTKRS 8-18）、鳞状细胞癌抗原（SCC）和癌抗原125（CA 125）检测。所有抗原的临界值选取为对照组标准高斯变量的第95百分位数；这些界限分别为TPA 98 U/L、TPS 127 U/L、Cyfra 21-1 1.6 ng/mL、CTKRS 8-18 1.2 ng/mL、CA 125 48 U/mL以及SCC 2.8 ng/mL。对于宫颈鳞状细胞癌，TPA与SCC具有相同的敏感性（42%），对于子宫内膜癌，TPA的敏感性高于CA 125（分别为40%和12%）。对于宫颈癌（40%对13%）和子宫内膜癌（40%对21%），TPA均比TPS更敏感。对于宫颈鳞状细胞癌，TPA和SCC比Cyfra 21-1（34%）和CTKRS 8-18（27%）更敏感。总之，至于可溶性细胞角蛋白片段，血清TPA似乎是宫颈癌和子宫内膜癌管理中最可靠的标志物。