Serratrice G, Pellissier J F, Faugere M C, Gastaut J L
Muscle Nerve. 1978 Jan-Feb;1(1):62-9. doi: 10.1002/mus.880010109.
The authors describe a case of myopathy characterized physically by limb weakness, eyelid ptosis, voluntary and reflex paralysis of vertical movements of gaze, and loss of deep tendon reflexes; and morphologically by the abnormal presence of centrally located nuclei in muscle fibers and type 1 fiber hypotrophy. The establishment in this case study of two particular findings--the probably nuclear or supranuclear ophthalmoplegia and the apparently impaired nuclear migration from the center of the muscle fiber toward its periphery--supports the hypothesis of a neuromuscular disorder whose level of severity depends on the degree of difficulty in the nuclear migration itself. This would be linked to a reduction in central nervous system influence.
作者描述了一例肌病病例，其身体特征为肢体无力、眼睑下垂、垂直注视的随意性和反射性麻痹以及深部腱反射消失；形态学特征为肌纤维中央核异常存在以及1型纤维萎缩。在该病例研究中确定的两个特殊发现——可能的核性或核上性眼肌麻痹以及肌纤维中央向周边的核迁移明显受损——支持了一种神经肌肉疾病的假说，其严重程度取决于核迁移本身的困难程度。这可能与中枢神经系统影响的降低有关。
