Iuminova N V, Krasnova V P, Liashenko V A, Vedunova S L
Vopr Virusol. 1993 May-Jun;38(3):111-3.
The search for alternative routes for administration of live measles vaccine is associated both with the threat of infection with human immunodeficiency virus, hepatitis B virus, and with the development of a more physiological, natural and less traumatic mode of vaccine administration. The influence of the intranasal administration on the general condition of the immune system, its immunomodulating effect (the emergence of inducer suppressors, cell response to the inactivated virus), was studied as well as the level and intensity of secretory and general humoral immunity. The studies confirmed the immunological effectiveness and safety of the intranasal administration of a live measles vaccine and suggested its advantages for revaccination against measles.
寻找麻疹活疫苗的替代给药途径，既与感染人类免疫缺陷病毒、乙型肝炎病毒的风险有关，也与开发更符合生理、更自然且创伤性更小的疫苗给药方式有关。研究了鼻内给药对免疫系统总体状况的影响、其免疫调节作用（诱导性抑制细胞的出现、细胞对灭活病毒的反应）以及分泌性和全身性体液免疫的水平和强度。这些研究证实了麻疹活疫苗鼻内给药的免疫有效性和安全性，并表明其在麻疹复种方面的优势。
