Combined chemoimmunotherapy of L5178Y lymphoma.

The antitumoral effect of chemotherapy and immunotherapy with BCG and/or irradiated L5178Y cells has been compared to antitumoral effect of chemotherapy alone. Significantly better results were noted in a transplantable L5178Y lymphoma grafted on DBA/2-J mice treated with methotrexate and BCG than in any other group which was not treated with BCG. The effect of irradiated lymphoma cells was similar to effectivity of methotrexate alone.