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博来霉素与苏云金芽孢杆菌以色列亚种δ-内毒素协同增强作用导致DNA链断裂增加，进而引起细胞毒性增强。

Enhanced cytotoxicity caused by increased DNA strand breakage resulting from synergistic potentiation of bleomycin with Bacillus thuringiensis subsp. israelensis delta-endotoxin.

作者信息

Yokoyama Y, Kohda K

机构信息

Tsukuba Research Laboratory, Toa Gosei Chemical Industry, Ibaraki, Japan.

出版信息

Anticancer Res. 1994 May-Jun;14(3A):837-40.

PMID:7521154
Abstract

We previously reported that a 25 kDa Bacillus thuringiensis subsp. israelensis (BTI) delta-endotoxin potentiates the cytotoxicity of bleomycin (BLM) in cultured cells. In order to clarify the mechanism involved, we examined the induction of DNA strand breakage by BLM in the presence of BTI toxin. Results showed that the increase in strand breakage resulted in enhanced cytotoxicity through the synergistic potentiation of BLM with BTI toxin.

摘要

我们之前报道过，一种25 kDa的苏云金芽孢杆菌以色列亚种（BTI）δ-内毒素可增强博来霉素（BLM）在培养细胞中的细胞毒性。为了阐明其中涉及的机制，我们检测了在BTI毒素存在的情况下博来霉素对DNA链断裂的诱导作用。结果表明，链断裂的增加通过博来霉素与BTI毒素的协同增强作用导致细胞毒性增强。

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