Yokoyama Y, Ohmori I, Suzuki H, Kohda K, Kawazoe Y
Tsukuba Research Laboratory, Toa Gosei Chemical Industry, Ibaragi, Japan.
Anticancer Res. 1992 Jul-Aug;12(4):1079-81.
We previously reported that a 25-kDa Bacillus thuringiensis subsp. israelensis (BTI) delta-endotoxin potentiated the antitumor activity of bleomycin (BLM) in both in vitro and in vivo systems. We report here a characteristic hyperthermic synergy toward the cytocidal activity of BLM in the presence of BTI endotoxin in cultured L1210 cells. Cytocidal gain, i.e., the ratio of the IC50 of BLM in the absence versus the presence of BTI delta-endotoxin, reached ca. 20 at 40 degrees C, suggesting that a more effective heat-BLM combination treatment may be achieved in the presence of BTI delta-endotoxin.
我们之前报道过，一种25 kDa的苏云金芽孢杆菌以色列亚种（BTI）δ-内毒素在体外和体内系统中均能增强博来霉素（BLM）的抗肿瘤活性。我们在此报告，在培养的L1210细胞中，在BTI内毒素存在的情况下，对BLM的杀细胞活性具有特征性的热协同作用。杀细胞增益，即不存在BTI δ-内毒素与存在BTI δ-内毒素时BLM的IC50之比，在40℃时达到约20，这表明在BTI δ-内毒素存在的情况下可能实现更有效的热-BLM联合治疗。
