Murr M M, Sarr M G, Oishi A J, van Heerden J A
Department of Surgery, Mayo Clinic, Rochester, Minnesota.
CA Cancer J Clin. 1994 Sep-Oct;44(5):304-18. doi: 10.3322/canjclin.44.5.304.
Pancreatic cancer is a devastating disease for the patient and presents challenging diagnostic and management problems for the physician. A range of serologic and radiologic studies are available for evaluation and staging of this disease. However, invasive studies, including laparotomy, are often necessary to establish the diagnosis and resectability. Despite advances in diagnostic technology that have shortened the interval between onset of symptoms and definitive treatment, no appreciable impact on survival has been demonstrated conclusively. Operative resection offers the only hope for cure, but fewer than 15 percent of patients have resectable disease at the time of diagnosis. Palliative therapy, whether operative or nonoperative, can be performed with low morbidity and provides significant relief of symptoms. Combined-modality treatment with chemotherapy and radiation therapy prolongs survival following curative resection.
胰腺癌对患者而言是一种极具毁灭性的疾病，给医生带来了具有挑战性的诊断和管理难题。一系列血清学和放射学检查可用于评估该疾病及进行分期。然而，包括剖腹手术在内的侵入性检查对于明确诊断和判断肿瘤是否可切除往往是必要的。尽管诊断技术取得了进步，缩短了症状出现到确诊治疗的间隔时间，但尚未确凿证明对生存率有显著影响。手术切除是治愈的唯一希望，但确诊时不到15%的患者肿瘤可切除。无论是手术还是非手术的姑息治疗，都能以较低的发病率进行，并能显著缓解症状。化疗和放疗的综合治疗可延长根治性切除术后的生存期。
